Naloxone - Toxicology Adult starting dose: - 0.4 mg IV/IM/IO/SQ for non-opioid dependent patients - 0.04 mg IV/IM/IO/SQ for opioid-dependent patients Pediatric starting dose: - 0.1 mg/kg IV/IM/IO/SQ for non-opioid dependent patients - 0.001 mg/kg IV/IM/IO/SQ for opioid-dependent patients Repeat with escalating doses every 2-3 minutes as needed If there is no response after 10-12 mg naloxone, search for other causes of CNS depression. If an infusion is required, it should be started at 2/3 the effective* naloxone dose per hour, and titrated as needed. *The ”effective” dose of naloxone is the dose that improved respiratory & CNS depression. A naloxone infusion in an adult can be prepared by multiplying the effective naloxone dose by 6.6, adding that quantity to 1000 ml of normal saline, and running the infusion at 100 ml/hr. Kat Watson @Kat_Watson #Naloxone #Narcan #Toxicology #Management #Pharmacology #Overdose
