Factors Indicating Low Risk Disease Severity in Crohn's Disease • Limited anatomic involvement • Only superficial luminal ulceration • No prior surgery or exposure to corticosteroids and/or immunosuppressive therapy • Mild symptoms (ambulatory patients, tolerating oral intake, stable weight and lack systemic symptoms and abdominal tenderness) • Low inflammatory burden Factors Indicating High Risk Disease Severity in Crohn's Disease • Large or deep mucosal lesions on endoscopy or imaging • Fistula and/or perianal abscess • Prior small bowel resection, presence of stoma • Extensive disease (ileal involvement >40cm, or pancolitis) • Strictures • Elevated CRP and/or anemia • Failure of anti TNF and/or immunosuppressive agents • Steroid use within last 1 yr • Symptoms of anorectal disease, daily abdominal pain Gregory Brennan MD @GregoryTBrennan #Crohns #Disease #Low #High #RiskFactors #Gastroenterology
