Antiplatelet Medications - Summary Table Aspirin - Inhibits cyclooxygenase, preventing formation of thromboxane A2 • Acute coronary syndrome (in combination with P2Y12 inhibitor and anticoagulation) • Acute stroke • Primary and secondary prevention of cardiovascular disease • Alternative to anticoagulation in a-fib P2Y12 Inhibitors (clopidogrel, prasugrel, ticagrelor) - Inhibits the P2Y12 ADP receptor, preventing platelet activation • Acute coronary syndrome (in combination with aspirin and anticoagulation) • Secondary prevention of stroke • As an alternative to aspirin in aspirin-allergic patients GP IIb/IIIa Inhibitors (eptifibatide, tirofiban, abciximab) - Inhibits the GP IIb/IIIa receptor, preventing platelet aggregation • Limited use peri-PCI in acute coronary syndrome Dipyridamole - PDE5 inhibition (and PDE3 inhibition to lesser extent) • Secondary stroke prevention (usually in combination with aspirin) • Use in myocardial nuclear imaging Cilostazol - PDE3 inhibition • Peripheral artery disease Dr. Eric Strong https://twitter.com/DrEricStrong #Antiplatelet #Medications #Summary #Table #Pharmacology
