Low-dose aspirin and low-molecular-weight heparin in lupus and Antiphospholipid Syndrome (APS) pregnancy • No previous history of thrombosis or pregnancy complications BUT high-risk aPL profile: Aspirin (75-100 mg/day) • Previous history thrombotic APS (arterial or venous): consensus +++ Aspirin (75-100 mg/day) + curative low-molecular-weight heparin (LMWH) • Previous history of obstetric APS: EULAR Recommendations 2019 - History of 23 recurrent spontaneous miscarriages weeks of gestation OR fetal loss > 10 weeks of gestation : Aspirin + preventive LMWH, continued for 6 weeks after delivery - History of delivery <34 weeks of gestation (eclampsia, preeclampsia or placental insufficiency): Aspirin ± preventive LMWH, continued for 6 weeks after delivery - History of "non-criteria" obstetric APS: Aspirin ± preventive LMWH, continued for 6 weeks after delivery By Dr. Chloé Baillou @BaillouChloe via Dr. Benjamin Terrier @TerrierBen #Antiphospholipid #Syndrome #APS #pregnancy #Obstetrics #Anticoagulation #Aspirin #LWMH #Dosing #Pharmacology
