Castleman's Disease and Associated Syndromes HYALINE VASCULAR VARIANT • unicentric, HHV8-ve, children and young. • Hyalinized vessels • Expanded mantle zone in concentric fashion- onion skin • Atrophic erminal center • Hyalinizeä blood vessel penetrating the follicle together-lollipop • Dysplastic FDC • Systemic symptoms usually absent • Pathogenesis: FDC abnormalities, Increased VEGF • 10-20% of FDC sarcoma are associated with Castleman's disease PLASMA CELL VARIANT • Hyperplastic germinal center • Diffuse plasma cells between follicles • Plasmablastic subtype is HHV8 + • Plasma cell variant can have hyaline vascular change- Mixed variant • Multicentric>unicentric • Systemic symptoms usually present • Pathogenesis "IL6 syndrome" Plasma cell disorders (myeloma, POEMS) HHV8, "Plasmablastic variant" Autoimmune diseases Dr. Hasan Faheema @faheema_hasan #Castlemans #Disease #Variants #Diagnosis #Pathology
