Osteomalacia & Osteoporosis in People with HIV Osteomalacia: - Decreased bone matrix mineralization. In people with HIV (rare): have been a/w TDF renal PO4 wasting, vitamin D deficiency (from multiple causes) - Bone pain/tenderness (back, legs, ribs), Proximal muscle weakness, waddling gait - XRay: Osteopenia, Looser's pseudofracture - Lab: Decr Ca, Decr PO4, Incr ALP, 25-OH-D <10, Incr PTH - Tx: Vitamin D, Tx of underlying cause; usual reversible Osteoporosis: - Loss of bone mass. In people with HIV (more common): multifactorial (viral effect, traditional risk factors, antiretroviral therapy) - Commonly asymptomatic - XRay: Osteopenia - Lab: Normal, mild-mod vitamin D deficiency - Tx: Bisphosphonates; varying response by WuidQ: Washington University ID Questions @WuidQ #Osteomalacia #Osteoporosis #HIVAIDS #Comparison #Diagnosis #TDF
