Lung Microbiome - The dysbiosis-inflammation cycle. Inflammation of the airways alters environmental growth conditions of airway microbiota via positive and negative selective pressures. Disordered growth conditions result in a disordered microbiome, which provokes further airway inflammation via pathogen-associated molecular pattern (PAMP)–pattern recognition receptor (PRR) interactions, via microbial metabolite signaling to leukocytes and epithelial cells, and via other pathways. This cascade results in a self-amplifying cycle of airway inflammation and respiratory dysbiosis. #Lung #Microbiome #dysbiosis #inflammation #cycle #pathophysiology #pulmonary
