Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia • NO underlying primary or secondary immune deficiencies • CD4 T-cell count of 300 cells/mL or 20% total lymphocyte on multiple occasions COMMON ASSOCIATIONS W/ LOW CD4 • Autoimmune (Sjogren, SLE, Kikuchi dz.) • Drugs (corticosteroids. chemotherapy) • Genetic syndromes (XMEN. WHIM. Unc119) • Heme (lymphoma. aplasia/myelodysplasia) • Infections - HIV. HTLV. EBV. CMV. MTB/MAC • Common variable immune deficiency • Sarcoidosis • Radiation therapy Dr. Kushal Vaishnani @k_vaishnani #Idiopathic #CD4 #Lymphopenia #ICL #diagnosis #hematology #Differential #Causes #lymphocytopenia
