Erythrocyte Sedimentation Rate (ESR) and C-reactive Protein (CRP) Here is a graphic on ESR and CRP. What can cause an ESR elevation with a normal CRP? Think Normal variation in elderly female, paraprotein, or active SLE (CRP elevation does not always correlate to disease activity). Dr. Ann Marie Kumfer @AnnKumfer #ESR #CRP #CReactiveProtein #ErythrocyteSedimentationRate #Diagnosis #Laboratory