Symmetrical Drug-Related Intertriginous and Flexural Exanthema (SDRIFE) 49M +burning rash groins/buttocks (pic in next thread) x 1d. No fever. 120/80,HR87. Exam: b/l warm,red patch groins/buttocks; no oral/palm lesion. WBC: 9. PMH: DM (A1c 6.5%; on canagliflozin), HTN (amlodipine), taking amox for a recent ear infection. Tx of this condition? 68% got the right answer, d/c culprit drug +/- steroids. The MCQ highlights a case of symmetrical drug-related intertriginous and flexural exanthema (SDRIFE). SDRIFE is a drug reaction uniquely characterized by: - symmetrical, well-demarcated, erythematous, confluent maculopapular rash/plaques in the upper/inner thighs, inguinal, gluteal areas Other features of SDRIFE: - also known as baboon syndrome (rash in the buttocks resembles that of baboons) - the rash can rarely exhibit pustules, blisters, or purpura - does not involve the palms/soles, face, or mucosal surfaces WuidQ: Washington University ID Questions @WuidQ #SDRIFE #Symmetrical #DrugRelated #Intertriginous #Flexural #Exanthema #rash #clinical #photo #dermatology
