Risk factors for hydroxychloroquine retinopathy - Daily dosage > 5.0 mg/kg ABW - Largest study suggests that ABW-based dosing offers improved prediction of retinopathy risk - Daily dosage >6.5 mg/kg IBW - Might additionally predict retinopathy, particularly in obese patients, although this association is controversial - Prolonged hydroxychloroquine - Minimal risk with <5 years use; risk continues to rise over 10—25 years of use - High cumulative dose - Some studies suggest increased risk with > 600-1000g exposure - CKD - Increased risk associated with stage 3, 4, or 5 CKD in largest recent study - Tamoxifen use - Increased risk associated with concomitant tamoxifen use for months in largest recent study #hydroxychloroquine #retinopathy #RiskFactors #ophthalmology
