Inherited forms of Hyperbilirubinemia Major pathways involved in bilirubin production, conjugation, and excretion. Notes: Both the UB and CB forms are bound by albumin in the plasma and interstitial space and by ligandin in the hepatocyte. The mechanism responsible for transporting unconjugated bilirubin into the hepatocyte has not been identified. Gilbert - Decreased UGT1A1 - Unconjugated Crigler-Najjar - Decreased/absent UGT1A1 - Unconjugated Dubin-Johnson - Decreased MRP2 - Conjugated Rotor - Decreased OATP1B - Conjugated https://pubmed.ncbi.nlm.nih.gov/252 #Inherited #forms #Hyperbilirubinemia #pathophysiology #congenital #hepatology #pediatrics #peds
