Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased Hepatic Uptake • Sepsis • Drugs (e.g. Rifampin) Decreased Conjugation • Gilbert's Syndrome • Crigler-Najjar Syndromes (l and II) Hepatic - Conjugated Hyperbilirubinemia • Hepatocellular • Cholestatic • Dubin Johnson Post-Hepatic - Usually has Duct Dilatation on Ultrasound Biliary Duct Compression • Malignancy • Metastases • Pancreatitis Intraductal Obstruction • Gallstones • Biliary Stricture • Cholangiocarcinoma • Primary Sclerosing Cholangitis #Jaundice #Differential #Diagnosis #Algorithm #Causes #Hepatology #bilirubinemia
