Bone Lesion on X-Ray - Differential Diagnosis Algorithm Exostotic • Osteochondroma Asymptomatic &/or Non-Active Bone Scam • Unicameral Bone Cysts • Aneurysmal Bone Cysts • Non-ossifying Fibroma Inflammatory Appearance • Osteoid Osteoma ("Nidus" appearance) • Osteoblastoma (may be malignant or sclerotic in appearance) Not Inflammatory Appearance • Chondroblastoma • Chondromyxoid Fibroma Multiple Lytic Lesions • Multiple Myeloma Benign - No Bone Mineralization • Enchondroma (can calcify &/or turn malignant) • Giant Cell Tumor ("Soap Bubble" appearance) Malignant - Bone Mineralization, Constitutional Symptoms, Codman's Triangle, Excessive Scalloping & Destruction of Cortical Bone • Osteosarcoma (Codman's Triangle) • Chondrosarcoma ("Popcorn" appearance) • Ewing's Sarcoma #Bony #Mass #Tumor #BoneLesion #XRay #MSK #Differential #Diagnosis #Algorithm #Orthopedics #Causes