Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex Hormones (LH, FSH, Testosterone, Estrogen) • Inhibit production of osteoblasts and GF's -> Osteoblasts and Growth Factors (GF's) • Decrease Vit-D (1-25-OH2) synthesis and action -> Decr Ca2+ Absorption, Incr Ca2+ Excretion • Upregulate gene expression of osteoclasts -> Incr Osteoclasts • Inhibit production of osteocytes -> Decr Osteocytes • Increase Marrow Fat -> Fat emboli -> Reduced Bone Formation, Increased Bone Resorption, Decreased Blood Supply #Glucocorticoids #steroids #Osteoporosis #pathophysiology #signs #symptoms #diagnosis
