Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations
• Immune Complex Deposition
- Arthralgia, Arthritis - Migratory, symmetrical, polyarticular, non-erosive
- Myalgia (40-80%) - Proximal Weakness, Normal CK
- Myositis (5-10%) - Proximal Weakness, Incr CK
• Bone marrow infarction, demineralization, and trabecular thinning -> Avascular / Osteonecrosis Esp. humeral and femoral heads
• Myopathy (Also caused by hydroxychloroquine therapy), Normal CK
• Osteoporosis
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