Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response -> Subacute cutaneous lupus: scaly annular lesions and plaques form in sun exposed areas -> Scaring alopecia • Red plaques with keratotic scaling that extend inflammation onto hair follicles -> causes follicular plugging -> Discoid Rash • UV light Incr cell death of keratinocytes but abnormal phagocytic removal of these cells -> Incr local inflammation on skin -> Malar (butterfly) Rash • ICx & immunoglobulin deposit at the dermal-epidermal junction (not restricted to mucous membranes) -> Mouth, Nasal Ulcers • Destruction of hair follicles due to inflammation (complex mechanism) -> Alopecia • Vasospasm of dermal arterioles and veins (decr release and activity of nitric oxide on endothelium) & Decr blood circulation to veins -> Livedo Reticularis, Vasculitis, Raynaud's Phenomenon #Lupus #SLE #Mucocutaneous #Manifestations #pathophysiology #diagnosis #signs #symptoms #complications
