Osteoarthritis (OA): Clinical findings • Stimulation of joint nociceptors in subchondral bone -> Pain with loading / use of joint • Disruption of normal joint architecture -> Palpable bony hypertrophy (ex. Bouchard's nodes) • Lack of cartilage means direct contact between bony processes with movement of the joint -> Crepitus • Impaction of osteophyte with normal joint structures during movement, Joint movement with reduced lubrication stimulates joint nociceptors -> Pain with motion, Decr range of motion • Dysregulation of proteolytic enzymes, joint fluid production -> Joint effusion #Osteoarthritis #OA #pathophysiology #diagnosis #signs #symptoms #complications
