Charcot Joint - Neuropathic Arthropathy: Pathogenesis and Clinical findings • Impaired joint protection -> abnormal joint movements -> Incr ROM, joint instability, ligamentous laxity over time • Joint mounts an inflammatory response -> Local swelling, warmth, & erythema, joint effusion, pain (variable dependent on degree of denervation) • Inflammatory cytokines act on osteoclasts to promote periarticular bone resorption -> On X-ray: osteopenia • Joint progresses from minor deformity -> major deformity -> Visibly abnormal joint: joint subluxation • Destruction of articular cartilage -> On X-ray: joint space narrowing • Inability to move joint, Interference with movement of limb -> Inability to ambulate: unsteady, antalgic gait #CharcotJoint #Neuropathic #Arthropathy #pathophysiology #diagnosis #signs #symptoms
