Acute Rheumatic Fever: Pathogenesis and Clinical Findings Delayed autoimmune reaction -> Molecular mimicry -> GAS antigen cross-reacts with host -> Activation of auto-reactive B and CD-4+ T cells -> Tissue injury and inflammation • Fever • Arthralgia • Erythema Marginatum • Subcutaneous Nodules (Osler's Nodes) • Increased ESR and CRP Neuronal cell surface targeted -> Cell signaling and dopamine release -> Sydenham's Chorea Lymphocytes adhere to myosin and cardiac proteins -> Pancarditis and valvular injury -> Prolonged PR Interval, Carditis #Acute #RheumaticFever #pathophysiology #diagnosis #signs #symptoms #complications
