Abnormal Lipid Profiles - Differential Diagnosis Algorithm
Increased Cholesterol and Triglycerides
- Genetic Causes
• Familial Combined Hyperlipidemia
• Familial Dysbetalipoproteinemia
- Secondary Causes
• Nephrotic Syndrome
• Drugs
• Diabetes
• Hypothyroidism
Decreased HDL
- Genetic Causes
• Apo-A1 Deficiency/ Variant
• Tangier Disease
• LCAT Deficiency
• Primary Hypo-alphalippproteinemia
- Secondary Causes
• Sedentary Lifestyle
• Smoking
• Androgens
Increased LDL
Genetic Causes
• Polygenic Hypercholesterolemia
• Familial
Hypercholesterolemia
• Familial Defective ApoB-100
• LDLr deficiency
Secondary Causes
• Hypothyroid
• Obstructive Liver Disease
• Nephrotic Syndrome
Increased Triglycerides
- Genetic Causes
• Familial Hypertriglyceridemia
• Familial LPL Deficiency
• Apo-Cll Deficiency
- Secondary Causes
• Diabetes
• Alcohol
• Increased Estrogen (e.g. Pregnancy, Hormone Replacement Therapy, Oral Contraceptive)
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