Third Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) Example: Aripiprazole Dopamine D2 Receptor Partial Agonist • Binds to the D2 receptor, then very quickly releases, then re-binds. This repetitive binding pattern does not allow for the normal dopamine molecules in the synapse to bind to the D2 receptor • Prevents excess DA from over-stimulating receptors, and deficient DA from under-stimulating receptors Serotonin 1A Partial Agonist • Bind to 5-HT 1A receptor in stabilizing manner, similar to D2-receptor agonism; does not allow excess or deficient 5-HT to over-stimulate or under-stimulate receptors • Antidepressant Effects #AntiPsychotics #ThirdGeneration #Mechanisms #SideEffects #pharmacology #diagnosis #psychiatry
