Paget’s Disease: Pathogenesis and Clinical Findings • Incr serum CTx - marker of bone resorption • Lytic bone lesions (mostly seen in pelvis, vertebral bodies, tibia, femur and skull) • Skeletal-deformities- e.g. Skull involvement (T hat size), Bowed tibias, kyphosis and fractures • Incr serum ALP - marker of bone formation #PagetsDisease #pathophysiology #diagnosis #signs #symptoms
