Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK • Deformed bones puts abnormal pressure on joints over time -> Osteoarthritis • Lytic lesions make bones weaker and more susceptible to breakage -> Pathologic fractures Renal • Incr Bone resorption, Incr renal [Ca2+] load, Incr urine [Ca2+] -> Nephrolithiasis (Kidney Stones) Cardiac • Extensive vascularity leads to high cardiac output -> Congestive Heart Failure (CHF) / Cardiomegaly Neurological • Disorganized growth of bone in vertebral column may narrow the vertebral canal & compress spinal nerve roots or the spinal cord itself -> Myelopathy or radiculopathy • Skull expansion causes narrowing of the foramina through which cranial nerves run, compressing the cranial nerve palsies -> Cranial Nerve Palsies • Disordered remodeling of middle ear bones causes middle ear dysfunction -> Conductive hearing loss #PagetsDisease #pathophysiology #diagnosis #signs #symptoms #complications
