Dupuytren’s Disease: Pathogenesis and Clinical Findings • Aging, smoking and/or diabetes -> Microangiopathy and palmar fascia ischemia releasing free radicals • Alcoholism -> Incr conversion of xanthine dehydrogenase to xanthine oxidase releasing free radicals • Trauma -> Generation of IL-1 and/or ischemia of palmar fascia • North European descent -> Autosomal dominant with variable penetrance • Males -> Expression of androgen receptors in fascia => Overproliferation of fibroblasts and type III collagen deposition in palmar/digital fascia => Dupuytren's: benign fibromatosis of palmar and digital fascia #Dupuytrens #Disease #Contractures #pathophysiology #msk
