Malignant Bone Tumors: Pathogenesis of X-ray appearance • Metastatic bone tumors (aka. cancerous cells from systemic locations that metastasized to the bone) are 200 times more common than primary bone tumors. • Metastatic bone tumors can often look differently from primary bone tumors on X-ray, depending on the source of metastasis: • Breast. prostate cancer bone metastases are often "radio-dense" (sclerotic lesions that look whiter than normal bone) - these cancer cells activate osteoblasts more than osteoclasts. • Lung. thvroid. and renal cancer bone metastases are often "radio-lucent" (osteolytic lesions that look darker than normal bone) - these cancer cells activate largely osteoclasts. Signs/Symptoms: • "Interrupted periosteal reaction ' • "Moth-eaten", permeative bone destruction • Wide zone of transition between bone and tumor (Ill-defined border) • Soft-tissue mass accumulation around the bone tumor #BoneTumors #Malignant #Radiology #Diagnosis #XRay #Bony
