Cholesteatoma (of middle ear): Pathogenesis and clinical findings • Congenital trapping of keratinizing epithelium in middle ear • Portion of eardrum retracts into middle ear • Ingrowth of keratinizing epithelium in middle ear => Cholesteatoma - Destructive growth of keratinizing squamous epithelium in the middle ear Signs / Symptoms / Complications • Visualization of mass in middle ear on otoscopy • Conductive hearing loss • Erosion of external auditory canal (EAC) • Aural Polyp secondary to inflammation • Acute otitis media • Coalescent Mastoiditis • Chronic otitis media • Facial nerve paralysis • Intracranial Infection (parenchymal abscess, meningitis, subdural abscess) • Conductive hearing loss • Labyrinthine fistula • Vertigo • Sensorineural hearing loss #Cholesteatoma #MiddleEar #pathophysiology #symptoms #signs #diagnosis #complications
