Cataract: Pathogenesis and clinical findings Increased Age (most common) -> Ultraviolet light, radiation, toxins ->Denaturation and abnormal structural changes to lens crystalline proteins -> Increased density, stiffening and pigmentation of lens material -> Opacification of crystalline lens => Cataract Formation Loss of transparency of natural lens -> Hardening of central lens nucleus -> Scattering of light -> Hyper-mature enlarged cataract • Blurred vision • Increased refractive power and nearsightedness • Glare and halos around lights -> poor night time driving • Decreased contrast sensitivity • Iris-trabecular meshwork contact -> Secondary angle closure glaucoma #cataracts #pathophysiology #ophthalmology
