Trachoma: Pathogenesis and clinical findings • Environmental Factors -> Bacterial infection is encouraged by poor hygiene and overcrowding in a hot, dry climate • Vectorial Transmission -> Eye-seeking flies (ex. Musca sorbens) transmit bacterium • Disease Reservoir -> Bacteria is transferred from person to person, usually from nasal or ocular secretions => Chlamydia trachomatous infection -> Follicles (collections of lymphocytes) appear in the superior tarsal conjunctiva, progressing to papillae -> Pannus (invasion by superficial vessels) of the limbal cornea -> Scarring of the peripheral cornea -> Extensive upper tarsal conjunctival scarring -> Subconjunctival fibrosis => • Corneal trauma • Decreased Lubrication • Dry eye => Blindness #Trachoma #Chlamydia #pathophysiology #ophthalmology
