Retinopathy of Prematurity: Pathogenesis and clinical findings Increased metabolic demand of growing eye -> Excessive VEGF production -> Neovascular complications -> Abnormal branching of vessels leading up to demarcation line -> Blood vessels enter ridge past demarcation line -> Blood vessels extend from the ridge into the vitreous -> Extra-retinal fibrovascular proliferation -> Contraction of fibrous tissue => Partial or complete retinal detachment #Retinopathy #Prematurity #peds #pediatrics #pathophysiology #ophthalmology
