Anaphylaxis: Signs and Symptoms Anaphylaxis: when any egg of three conditions is met: 1. Acute onset of skin/mucosal involvement with 2 1 of' • respiratory compromise • hypotension 2. Rapid onset of symptoms after exposure to a likely allergen with >2 of: • skin/mucosal symptoms • respiratory symptoms • hypotension • persistent GI symptoms 3. Hypotension after exposure to known allergen Note: Severity of symptoms in the acute phase does not necessarily predict occurrence of late phase symptoms Signs / Symptoms / Complications: • Abdominal cramping, vomiting, diarrhea • Wheezing, dyspnea, hypoxia • Angioedema • Flushing • Hypotension -> Circulatory collapse -> - Neurological Compromise (e.g. syncope, seizures) - Cardiac Compromise (e.g. arrythmias, ischemia) • Urticaria • Angioedema #Anaphylaxis #pathophysiology #immunology #diagnosis #signs #symptoms