Feedback Loop: Prolactin (PRL) • PRL levels exhibit diurnal, menstrual, and age-related variation • TRH has a stimulatory effect on PRL release; however, dopamine is the principal regulator of PRL secretion Prolactin (PRL): • Hypothalamus -> Decr GnRH secretion -> Decr FSH/LH -> Decr estradiol in females, Decr testosterone in males • Limbic System -> Decr Libido • Immune System Organs -> Promotes proliferation and maturation of immune cells • Alveolar Cells of Breast Ducts -> Milk production and release -> Lactation #Prolactin #PRL #FeedbackLoop #endocrinology #pathophysiology #pituitary
