Feedback Loop: Growth Hormone (GH)
Growth Hormone:
• Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
• Bone - IGFIR activates osteoblasts and chondrocytes -> Incr ossification
• Muscle -> GHR activates JAK-STAT pathway -> Incr gene expression/protein synthesis of IGF1R -> Activation of AKT pathway -> Incr cell growth & survival
• Adipose Tissue -> GHR activates lipolysis
Signs/Symptoms:
• GH deficiency:
- Short stature
- Decr strength
- Incr fat mass, abn lipid
• GH excess:
- Giantism or acromegaly, widening of hands/feet
- Soft tissue expansion (e.g. carpal tunnel, OSA, Incr skin thickness)
- metabolic abn
#GrowthHormone #GH #FeedbackLoop #endocrinology #pathophysiology #pituitary
