Graves’ Disease: Pathogenesis and Clinical Findings B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous stimulation of thyrotropin receptor by circulating autoantibodies -> Increased iodination of thyroglobulin, Thyroid gland hyperplasia Note: B & T lymphocytes also attack other thyroid antigens (thyroglobulin, thyroid peroxidase, Na-I Symporter) but is believed to play little role in the etiology Signs/Symptoms: - Pretibial myxedema - Fat pad: proptosis - Muscle: diplopia - Conjunctiva: conjunctivitis - Decr TSH - Goiter -> Hoarseness, Dysphagia, Thyroid gland bruit #GravesDisease #pathophysiology #endocin #endocrinology #symptoms #signs #diagnosis
