Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies ex. SCD, thalassemias • Membrane defects ex. Hereditary spherocytosis / elliptocytosis Extrinsic Causes: • Liver disease • Hypersplenism • AIHA: warm, cold, drug induced • Infections ex. Bartonella, Babesia, Malaria • Oxygen agents ex. dapsone, nitrates • Other agents ex. lead, copper, spider/snake bites • IVIG infusion Intravascular Causes: • MAHA: TTP, HUS, DIC, HELLP, AS, prosthetic valve • Transfusion reactions ex. ABO incompatibility • Paroxysmal Nocturnal Hemoglobinuria • S/p IV infusion of Rhogam • S/p IV infusion of hypotonic solutions Dr. Uday Gulati @udaygulati #Hemolytic #Anemia #Differential #Diagnosis #causes #classification #hematology
