Hyperuricemia - Differential Diagnosis Algorithm
Primary - Over-production
• Increased turnover of nucleotides
Primary - Under-excretion
• Lower uric acid clearance
• Starvation
Secondary - Over-production
- Lymphoproliferative Disorders
• Acute Lymphoblastic Leukemia (ALL)
• Acute Myeloid Leukemia (AML)
• Chronic Myeloid Leukemia (CML)
- Hemolytic Anemia
- Others
• Psoriasis
• Chemotherapy
• Drug-induced
• High purine diet
Secondary - Under-excretion
- Endocrine
• Hyperparathyroidism
• Diabetic acidosis
- Renal
• Chronic renal failure
• Sarcoidosis
• Hypercalcemia
- Drug-Induced
• Antiuricosuric drugs
• ACE inhibitors
• Cyclosporine
• Diuretics
• Organic acids
• Ethambutol
• Alcohol
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