Tall Stature - Differential Diagnosis Algorithm
Normal Growth (BA=CA)
• Familial Tall Stature
• XYY Syndrome
Obese BMI
• Exogenous Obesity
Normal Puberty Onset
• GH Excess
• Hyperthyroidism
Precocious Puberty
• Adrenal Tumor
• Ovarian Tumor
• Testotoxicosis
• Congenital Adrenal Hyperplasia
Constitutional
• Constitutional Tall Stature (Early Bloomer)
Other Obvious Abnormalities/Stigmata - Disproportionate
• Klinefelter's Syndrome
• Soto's Syndrome/ Cerebral Gigantism
• Marfan's Syndrome
• Homocystinuria
• Sex Steroid Deficiency/Resistance
• Acromegaly (Rare in Children)
Other Obvious Abnormalities/Stigmata - Proportionate
• Bechwith-Weidmann Syndrome (Normalizing growth after birth)
• Weaver Syndrome
• XYY Syndrome
• Neurofibromatosis 1
• Hyperthyroidism (Untreated/Severe)
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