Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis Algorithm
Neoplasm:
• NHL
• Hodgkin's lymphoma
• Leukemia
• Solid tumors
Autoimmune:
• SLE
• Polyarteritis nodosum
• Giant cell arteritis
• Sarcoidosis
Other:
• Drug fever
• Factitious fever
• Trauma Non-infectious hepatitis
• Recurrent PE
Bacterial - Organ Specific Infection
• Infectious endocarditis
• Osteomyelitis
• Occult abscess
• Sinusitis
• Cholangitis
• UTI
• Meningitis
Bacterial - Non-organ specific
• Brucellosis
• Q-fever
• Salmonella
• Yersinia
• Tuleremia
• Septic Phlebitis
• Rheumatic fever
• Lyme disease
• Whipple's disease
Viral Infection:
• HIV
• EBV
• CMV
• Viral hepatitis
• Enterovirus
Other Infection:
• Fungal
• Protozoa (eg. malaria)
• other parasites
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