Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
• Cardio-pulmonary disease
• Anemia
• Chronic Infection
• Malignancy
• Depression
• Deconditioning
• Arthritis
• Fibromyalgia
• Endocrine Disease
Motor Neuron and Motor Neuropathy - Atrophy, Fasciculations, Hyperreflexia
• Lead toxicity
• Progressive muscular atrophy
• Hodgkin's lymphoma
• Polio
• Multifocal Motor Neuropathy
• Spinal Muscular Atrophy
Neuromuscular Junction - Fatigability, Variability, Oculomotor
• Myasthenia Gravis
• Lambert-Eaton Myasthenic Syndrome
• Botulism
• Congenital
Myopathy - Proximal muscle involvement, elevated CK
• Polymyositis
• Duchenne Muscular Dystrophy
• Statin Toxicity
• Dermatomyositis
• Viral infection
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