Causes of Chronic Kidney Disease - Differential Diagnosis Algorithm Decreased kidney function (eGFR < 60 ml/min/1.73 m2) persistent over at least 3 months Pre-Renal (Evidence of Renovascular disease) • Atheroemboli • Renal artery stenosis • Drugs • Chronic hypoperfusion Post-Renal (Obstruction/hydronephrosis on U/S) • Reflux nephropathy • Benign prostatic hyperplasia • Constipation • Prostate cancer Tubular (Family history, ultrasound) • Polycystic kidney disease • Medullary cystic disease • Nephronophthisis Vascular (Other small vessel disease) • Atherosclerosis Glomerular (Proteinuria) • Diabetes • Hypertension Interstitial (Sterile pyuria, WBC casts, eosinophiluria) • Drugs (NSAlDs, analgesics) • Infections (chronic pyelonephritis) • Immune (sarcoid, Sjögren) • Multiple myeloma • Hyperoxaluria • Hypercalcemia • Hyperphosphatemia #CKD #Chronic #KidneyDisease #Nephrology #Differential #Diagnosis #Algorithm #Causes
