Causes of Hyperkalemia - Intercellular Shift - Differential Diagnosis Algorithm Transcellular Shift - Appropriate renal excretion (GFR, TTKG, distal flow adequate) Increased Release - Increased Serum Osmoles, Increased Urate, Phosphate, Creatinine Kinase • Non-Anion Gap Metabolic Acidosis • Hyperosmolarity • Cell Lysis (e.g. Tumor Lysis Syndrome, rhabdomyolysis) Decreased Entry - Decreased Na+-H+ Exchanger, Decreased Na+-K+-ATPase • Insulin Deficiency/Resistance • Beta-2 antagonism • alpha-1 agonism • Digoxin #Hyperkalemia #IntercellularShift #Nephrology #Differential #Diagnosis #Algorithm #Causes
