Causes of Hyponatremia - Differential Diagnosis Algorithm Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to ADH • Pain/Post-op • Neurologic trauma • Drugs • Pulmonary pathology • Malignancy True hypovolemia • Bleeding • GI losses • Renal losses (especially thiazide diuretics) With edema • Congestive heart failure • Cirrhosis • Nephrotic syndrome • Reduced GFR, AKI/CRF Hormonal changes • Hypothyroidism • Adrenal insufficiency • Pregnancy Hypo-osmolar urine - Uosm < 100 mmol/kg - ADH suppression • Primary polydipsia • Insufficient osmole intake #Hyponatremia #Nephrology #Differential #Diagnosis #Algorithm #Causes
