Causes of Metabolic Acidosis with Elevated Anion Gap - Differential Diagnosis Algorithm Elevated Anion Gap > 12 (Gain of H+) - Need to correct anion gap for albumin: For every drop of 10 for albumin (from 40) add 2.5 to the anion gap Decreased NH4 production and anion secretion • AKI/CKD Salicylate poisoning Lactic acidosis • Shock • Drugs • Inborn errors Ketosis • Diabetic ketoacidosis • Starvation/alcoholic Ketosis Toxic alcohol ingestion • Ethylene/Propylene glycol • Methanol Other ingestion • Paraldehyde, Iron, Isoniazid, Toluene, Cyanide #MetabolicAcidosis #AnionGap #Nephrology #Differential #Diagnosis #Algorithm #Causes
