Causes of Non-Gap Metabolic Acidosis - Differential Diagnosis Algorithm Normal Anion Gap (<14) (Loss of Bicarbonate) - Need to correct anion gap for albumin: For every drop of 10 for albumin (from 40) add 2.5 to the anion gap GI Tract Loss (Negative urine net charge) • Diarrhea • Fistula Renal Loss - Direct Loss Negative U net charge High FE-HCO3 • RTA Type II • Carbonic anhydrase inhibitor Principal Cell Problem - Low TTKG • RTA Type IV Alpha-Intercalated Cell Problem - High TTKG • RTA Type I #MetabolicAcidosis #NonGap #Nephrology #Differential #Diagnosis #Algorithm #Causes
