Causes of Fat Malabsorption - Differential Diagnosis Biliary Duct Obstruction • Autoimmune— PBC, PSC • Infection— liver fluke, HIV, CMV, ascariasis • Malignancy— cholangiocarcinoma • Other— choledocho/ithiasis Intestinal Wall Infiltration • Malignancy— lymphoma • Autoimmune— Crohn's disease, celiac disease • Immunodeficiency— CVID • Protein- amyloidosis Other: • Cholestatic drugs- e.g. azathioprine, phenytoin Pancreatic Exocrine Insufficiency - Acquired • Chronic pancreatitis • Pancreatic resection Pancreatic Exocrine Insufficiency - Hereditary • Hemochromatosis • Shwachman-Diamond syndrome • Cystic fibrosis • Pancreatic lipase deficiency Pancreatic Exocrine Insufficiency - Malignancy • Pancreatic adenocarcinoma • Gastrinoma Autoimmune • Celiac disease • IBD- CD, UC Altered length • Short bowel syndrome • Small bowel resection Infectious • SIBO • Giardiasis • Whipple' disease • Tropical sprue • HIV enteropathy Nikita Deshpande @NikitaSonaliyaD #Fat #Malabsorption #Differential #Diagnosis #Causes
