Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
- Systemic Inflammatory
• Systemic Lupus Erythematosus
• Sarcoidosis
• Rheumatoid Arthritis
• Pseudotumor
- Infectious
• EBV
• CMV
• HIV
• Tuberculosis
• Hepatitis
- Other
• Acne
• Allergy
• Insect Bites
• Young age
Neoplastic:
- Leukemia - History of Bleeding, Infection, Fatigue
• Acute Lymphoblastic Leukemia (Pancytopenia, WBC differential includes Blasts)
- Leukemia - Asymptomatic, Age > 50
• Chronic Lymphocytic Leukemia (CBC with Lymphocytes)
- Monoclonal Lymphocytes on Biopsy
• Non-Hodgkin's Lymphoma
- Reed-Sternberg Cells on Biopsy
• Hodgkin's Lymphoma
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