Causes of Polycythemia (Erythrocytosis) - Differential Diagnosis Algorithm Relative - Normal RBC Mass / Decreased Plasma Volume • Burns • Diarrhea • Dehydration • Idiopathic JAK-2 Positive - Low/Normal Erythropoietin, O2 Saturation > 90%, Splenomegaly, Increased PMNs • Polycythemia Vera Erythropoietin Secreting Tumor - O2 Saturation 90%, Abnormal Abdominal Ultrasound High Affinity Hemoglobin - O2 Saturation > 90%, Increased carboxyhemoglobin, Abnormal P450 determination, Smoking, positive Family History, early onset • Congenital Hemoglobinopathy • Familial Polycythemia • Carboxyhemoglobin Heart Murmur, Cyanosis without Pulmonary Disease • Cyanotic Heart Disease Abnormal Chest X-Ray, Shortness of Breath, Cough, Smoking, Snoring Chronic Chest Symptoms • Sleep Apnea • Chronic Pulmonary Disease #Polycythemia #Erythrocytosis #Differential #Diagnosis #Algorithm #Causes #Hematology
