Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g. Chemotherapy) • Displacement (e.g. Leukemia, Tumour) Ineffective Megakaryopoiesis • B12 Deficiency • Folate Deficiency • Folate Antagonist (methotrexate) • Drugs Autoimmune • ITP • SLE • CLL • APLA Alloimmune • anti-HLA antibodies Drugs • Quinidine • HIT • Others Non-lmmune: • HELLP Syndrome • TTP/HUS • DIC • Vasculitis • Infection • Foreign Surface (e.g. Prosthetic Heart Valve) #Thrombocytopenia #Differential #Diagnosis #Algorithm #Causes #Hematology
