Causes of Hypotonic Infant (Floppy Newborn) - Differential Diagnosis Algorithm
Central Nervous System - Decreased LOC, Axial Weakness, Normal Strength, Normal Reflexes
- Brain
• Hypoxic-Ischemic Encephalopathy*
• Trisomy 21*
• Intracranial Hemorrhage
• CNS Infection
• Metabolic Diseases
• Prader-Willi
• Intracranial Mass/lesion
• Other Congenital Syndromes
- Spinal Cord
• Spinal Muscular Atrophy
• Trauma
• Hematoma
• Abscess
• Arteriovenous Fistula
• Infantile Neuronal Degeneration
• Poliomyelitis
Peripheral Nervous System - Alert, Responding to Surroundings, Profound Peripheral Weakness
- Nerves
• Congenital Hypomyelinating Neuropathy
• Infantile Neuroaxonal Degeneration
- Neuromuscular Junction
• Congenital and Transient Myasthenia Gravis
• Infantile Botulism
• Magnesium Toxicity
• Aminoglycoside Toxicity
- Muscle
• Congenital Myotonic Dystrophies
• Metabolic Myopathies
• Central Core Disease
• Other Congenital Myopathies
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