Causes of Fever: IMADE Mnemonic INFECTION • Infection 1.0 - Common & Localizing: Base Rate • Infection 2.0 - Beyond The Base Rate: Tick-Borne. Fungal, TB, etc. MALIGNANCY • Leukemia & Lymphoma >> Solid Cancers +/- Hepatic Metastases • Pearl: 20% of renal cell carcinomas present with fever! AUTOIMMUNE • SLE • Adult-Onset Stills Disease • Schnitzler • GPA • Vasculitides • Myosites DRUGS • SJS-TEN: lamotrigine, valproate. carbamezapine, sulfa drugs, aminopenicillins. allopurinol, oxicam NSAlDs • DIHS: allopurinol. carbamezapine. lamotrigine. phenytoin. sulfasalzine. vancomycin, minocycline, dapsone. sulfamethoxazole • NMS: neuroleptics, antipsychotics • Others: antihistamines. amphetamines, hydralazine. methyldopa. antithyroids DVT/PE • Thrombosis leads to increased inflammtory cytockines (IL-I, IL-6, IL-8, TNF-alpha)! Heparin itself has anti-inflammatory properties. and avoid premature closure with DVT/PE + fever. ENDOCRINE • Most commonly associated with hyperthyroidism. Also think about subacute thyroiditis, adrenal insufficiency, or pheochromocytoma #Fever #IMADE #Mnemonic #Causes #IMADDE #diagnosis #differential
